Team

Dr. Jake Brenner, MD, PhD is an assistant professor & attending physician in the University of Pennsylvania’s (Penn) Departments of Medicine and Pharmacology. He joined the Penn faculty in 2018, where he spends 6 weeks each year taking care of patients in the ICU, and the rest developing genetic medicine & drug delivery technologies. His lab primarily delivers RNA and DNA via targeted lipid nanoparticles (LNPs). The lab has also identified multiple innate immune mechanisms activated by LNPs, and then engineered solutions, to build safer, more effective LNPs. The lab is funded by government grants and by several companies, and has spun out multiple medical technology companies.