Publications
Selected papers
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Multi-stage-mixing to create a core-then-shell structure improves DNA-loaded lipid nanoparticles transfection by orders of magnitude
Enabling non-viral DNA delivery using lipid nanoparticles co-loaded with endogenous anti-inflammatory lipids
Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape without Side Effects
Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation
Zaleski MH, Chase LS, Hood ED, Wang Z, Nong J, Espy CL, Zamora ME, Wu J, Morrell LJ, Muzykantov VR, Myerson JW, Brenner JS
A percolation-type criticality threshold controls immune protein coating of surfaces
Wang Z, Kulkarni S, Nong J, Zamora ME, Ebrahimimojarad A, Hood E, Shuvaeva T, Zaleski M, Gullipalli D, Wolfe E, Espy C, Arguiri E, Wang Y, Marcos-Contreras OA, Song W, Muzykantov VR, Fu J, Radhakrishnan R, Myerson JW, Brenner JS
Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy
Zaleski MH, Omo-Lamai S, Nong J, Chase LS, Myerson JW, Glassman PM, Lee F, Reyes-Esteves S, Wang Z, Patel MN, Peshkova AD, Komatsu H, Axelsen PH, Muzykantov VR, Marcos-Contreras OA, Brenner JS
Neutrophil-avid nanocarrier uptake by STAT3 dominant-negative hyper-IgE syndrome patient neutrophils
Rubey KM, Freeman A, Mukhitov AR, Paris AJ, Lin SM, Rue R, Fazelinia H, Spruce LA, Roof J, Brenner JS, Heimall J
Drug overdose vital-signs evaluator using machine learning
Lingamoorthy AN, Mishra AK, Kumar S, Gordon D, Brenner J, Kandasamy N, Watson A
Controlling spatial distribution of functional lipids in a supported lipid bilayer prepared from vesicles
Lee HS, Kim YC, Wang Z, Brenner JS, Muzykantov VR, Myerson JW, Composto RJ
Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system
Zamora ME, Essien E, Bhamidipati K, Murthy A, Liu J, Kim H, Patel MN, Nong J, Wang Z, Espy C, Chaudhry FN, Fergudon LT, Tiwari S, Hood ED, Marcos-Contreras OA, Omo-Lamai S, Shuvaeva T, Arguiri E, Wu J, Rauova L, Poncz M, Basil MC, Cantu E, Planer JD, Spiller K, Zepp J, Muzykantov VR, Myerson JW, Brenner JS
Targeting of nanoparticles to the cerebral vasculature after traumatic brain injury
Omo-Lamai S, Nong J, Savalia K, Kelley BJ, Wu J, Esteves-Reyes S, Chase LS, Muzykantov VR, Marcos-Contreras OA, Dollé JP, Smith DH, Brenner JS
TSC2 loss in neural progenitor cells suppresses translation of ASD/NDD-associated transcripts in an mTORC1- and MNK1/2-reversible fashion
Martin P, Szkop KJ, Robert F, Bhattacharyya S, Beauchamp RL, Brenner JS, Redmond NE, Huang S, Erdin S, Larsson O, Ramesh V
Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions
Anchordoquy T, Artzi N, Balyasnikova IV, Barenholz Y, La-Beck NM, Brenner JS, Chan WC, Decuzzi P, Exner AA, Gabizon A, Godin B, Lai SK, Lammers T, Mitchell MJ, Moghimi SM, Muzykantov VR, Peer D, Nguyen J, Popovtzer R, Ricco M, Serkova NJ, Singh R, Schroeder A, Schwendeman AA, Straehla JP, Teesalu T, Tilden S, Simberg D
Developing targeted antioxidant nanomedicines for ischemic penumbra: Novel strategies in treating brain ischemia-reperfusion injury
Hou Z, Brenner JS
Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke
Nong J, Glassman PM, Shuvaev VV, Reyes-Esteves S, Descamps HC, Kiseleva RY, Papp TE, Alameh MG, Tam YK, Mui BL, Omo-Lamai S, Arguiri E, Gong X, Brysgel TV, Tan AW, Woolfork AG, Weljie A, Thaiss CA, Myerson JW, Weissman D, Kasner SE, Parhiz H, Muzykantov VR, Brenner JS, Marcos-Contreras OA
A Robust and Efficient Method to Purify DNA-Scaffolded Nanostructures by Gravity-Driven Size Exclusion Chromatography
Ebrahimimojarad A, Wang Z, Zhang Q, Shah A, Brenner JS, Fu J
Combination of physicochemical tropism and affinity moiety targeting of lipid nanoparticles enhances organ targeting
Zamora ME, Omo-Lamai S, Patel MN, Wu J, Arguiri E, Muzykantov VR, Myerson JW, Marcos-Contreras OA, Brenner JS
Anaerobic Lactate Production Is Associated With Decreased Microcirculatory Blood Flow and Decreased Mitochondrial Respiration Following Cardiovascular Surgery With Cardiopulmonary Bypass
Greenwood JC, Talebi FM, Jang DH, Spelde AE, Gordon EK, Horak J, Acker MA, Kilbaugh TJ, Shofer FS, Augoustides JG, Brenner JS, Muzykantov VR, Bakker J, Abella BS
Physicochemical targeting of lipid nanoparticles to the lungs induces clotting: mechanisms and solutions
Omo‐Lamai S, Zamora ME, Patel MN, Wu J, Nong J, Wang Z, Peshkova A, Majumder A, Melamed JR, Chase LS, Essien EO, Weissman D, Muzykantov VR, Marcos‐Contreras OA, Myerson JW, Brenner JS
Low postoperative perfused vessel density is associated with increased soluble endothelial cell adhesion molecules during circulatory shock after cardiac surgery
Greenwood JC, Talebi FM, Jang DH, Spelde AE, Gordon EK, Horak J, Acker MA, Kilbaugh TJ, Shofer FS, Augoustides JG, Bakker J, Brenner JS, Muzykantov VR, Abella BS
Automated measurement of distance-walked as a “sixth vital sign” for detecting infusion reactions during preclinical testing
Chase LS, Zaleski MH, Morrell LJ, Brenner JS
Effective Prevention of Arterial Thrombosis with Albumin-Thrombin Inhibitor Conjugates
Marcos-Contreras OA, Myerson JW, Nong J, Brenner JS, Muzykantov VR, Glassman PM
Does acupuncture have advantages in the rehabilitation of vascular mild cognitive impairment? A systematic review and meta-analysis
Hou Z, Yu X, Chen J, Brenner JS, Sun Z, Shang H
Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain
Nong J, Glassman PM, Myerson JW, Zuluaga-Ramirez V, Rodriguez-Garcia A, Mukalel A, Omo-Lamai S, Walsh LR, Zamora ME, Gong X, Wang Z, Bhamidipati K, Kiseleva R, Villa CH, Greineder CF, Kasner SE, Weissman D, Mitchell MJ, Muro S, Persidsky Y, Brenner JS, Muzykantov VR, Marcos-Contreras OA
Dove: shoulder-based opioid overdose detection and reversal device
Lingamoorthy A, Watson A, Gordon D, Mandal A, Henderson K, Ma X, Weimer J, Brenner J, Kandasamy N
Meta-analysis of material properties influencing nanoparticle plasma pharmacokinetics
Macedo B, Patel M, Zaleski MH, Mody P, Ma X, Mei P, Myerson JW, Brenner JS, Glassman PM
Targeted drug delivery to the brain endothelium dominates over passive delivery via vascular leak in experimental intracerebral hemorrhage
Reyes-Esteves S, Nong J, Glassman PM, Omo-Lamai S, Ohashi S, Myerson JW, Zamora ME, Ma X, Kasner SE, Sansing L, Muzykantov VR, Marcos-Contreras OA, Brenner JS
Mechanisms by which liposomes improve inhaled drug delivery for alveolar diseases
Ferguson LT, Ma X, Myerson JW, Wu J, Glassman PM, Zamora ME, Hood ED, Zaleski M, Shen M, Essien EO, Shuvaev VV, Brenner JS
Topical nitroglycerin to detect reversible microcirculatory dysfunction in patients with circulatory shock after cardiovascular surgery: an observational study
Greenwood JC, Talebi FM, Jang DH, Spelde AE, Tonna JE, Gutsche JT, Horak J, Acker MA, Kilbaugh TJ, Shofer FS, Augoustides JG, Bakker J, Brenner JS, Muzykantov VR, Abella BS
Protocol for the MicroRESUS study: The impact of circulatory shock and resuscitation on microcirculatory function and mitochondrial respiration after cardiovascular surgery
Greenwood JC, Talebi FM, Jang DH, Spelde AE, Kilbaugh TJ, Shofer FS, Acker MA, Augoustides JG, Bakker J, Meyer NJ, Brenner JS, Muzykantov VR, Abella BS
Nanoparticle-induced augmentation of neutrophils’ phagocytosis of bacteria
Rubey KM, Mukhitov AR, Nong J, Wu J, Krymskaya VP, Myerson JW, Worthen GS, Brenner JS
Targeted in vivo loading of red blood cells markedly prolongs nanocarrier circulation
Glassman PM, Villa CH, Marcos-Contreras OA, Hood ED, Walsh LR, Greineder CF, Myerson JW, Shuvaeva T, Puentes L, Brenner JS, Siegel DL, Muzykantov VR
Imatinib alleviates lung injury and prolongs survival in ventilated rats
Xin Y, Cereda M, Yehya N, Humayun S, Delvecchio P, Thompson JM, Martin K, Hamedani H, Martorano P, Duncan I, Kadlecek S, Makvandi M, Brenner JS, Rizi RR
Targeting ligand surface density controls both complement activation and targeting efficiency of immunoliposomes
Nong J, Glassman PM, Wang Z, Marcos‐Contreras OA, Brenner JS, Muzykantov VM
Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)
Parhiz H, Brenner JS, Patel PN, Papp TE, Shahnawaz H, Li Q, Shi R, Zamora ME, Yadegari A, Marcos-Contreras OA, Natesan A, Pardi N, Shuvaev VV, Kiseleva R, Uhler T, Riley RS, Han X, Mitchell MJ, Lam K, Heyes J, Weissman D, Muzykantov VR
Dual affinity to RBCs and target cells (DART) enhances both organ-and cell type-targeting of intravascular nanocarriers
Ferguson LT, Hood ED, Shuvaeva T, Shuvaev VV, Basil MC, Wang Z, Nong J, Ma X, Wu J, Myerson JW, Marcos-Contreras OA, Katzen J, Carl JM, Morrisey EE, Cantu E, Villa CH, Mitragotri S, Muzykantov VR, Brenner JS
Targeted nanocarriers coopting pulmonary leukocytes for drug delivery to the injured brain
Glassman PM, Nong J, Myerson JW, Zuluaga-Ramirez V, Rodriguez-Garcia A, Mukalel A, Omo-Lamai S, Walsh LR, Kiseleva RY, Villa CH, Greineder CF, Kasner SE, Weissman D, Mitchell MJ, Muro S, Persidsky Y, Brenner JS, Muzykantov VR, Marcos-Contreras OA
Combating Complement's Deleterious Effects on Nanomedicine by Conjugating Complement Regulatory Proteins to Nanoparticles (Adv. Mater. 8/2022)
Wang Z, Hood ED, Nong J, Ding J, Marcos‐Contreras OA, Glassman PM, Rubey KM, Zaleski M, Espy CL, Gullipali D, Miwa T, Muzykantov VR, Song WC, Myerson JW, Brenner JS
Willingness to use a wearable device capable of detecting and reversing overdose among people who use opioids in Philadelphia
Kanter K, Gallagher R, Eweje F, Lee A, Gordon D, Landy S, Gasior J, Soto-Calderon H, Cronholm PF, Cocchiaro B, Weimer J, Roth A, Lankenau S, Brenner JS
Nanomedicine to fight infectious disease
Rubey KM, Brenner JS
Wearable biosensors have the potential to monitor physiological changes associated with opioid overdose among people who use drugs: A proof-of-concept study in a real-world setting
Roth AM, Tran NK, Cocchiaro B, Mitchell AK, Schwartz DG, Hensel DJ, Ataiants J, Brenner J, Yahav I, Lankenau S
Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment.
Myerson JW, Patel PN, Habibi N, Walsh LR, Lee Y-W, Luther DC, Ferguson LT, Zaleski MH, Zamora ME, Marcos-Contreras OA, Glassman PM, Johnston I, Hood ED, Shuvaeva T, JV, Kiseleva RY, Nong J, Rubey KM, Greineder CF, Mitragotr S, Worthen GS, Rotello VM, Lahann J, Muzykantov VR, Brenner JS.
Red blood cells: The metamorphosis of a neglected carrier into the natural mothership for artificial nanocarriers
Glassman PM, Hood ED, Ferguson LT, Zhao Z, Siegel DL, Mitragotri S, Brenner JS, Muzykantov VR
Red blood cell hitchhiking: a novel approach for vascular delivery of nanocarriers
Brenner JS, Mitragotri S, Muzykantov VR
Nanocarriers Targeting Intercellular Adhesion Molecule Enhance Delivery to the Inflamed Brain
Nong J, Marcos‐Contreras OA, Glassman P, Brenner JS, Muzykantov VR
COVID-19 and the early-career physician-scientist. Fostering resilience beyond the pandemic
Kliment CR, Barbash IJ, Brenner JS, Chandra D, Courtright K, Gauthier MC, Robinson KM, Scheunemann LP, Shah FA, Christie JD, Morris A
Targeting drug delivery in the vascular system: Focus on endothelium
Glassman PM, Myerson JW, Ferguson LT, Kiseleva RY, Shuvaev VV, Brenner JS, Muzykantov VR
Vascular Drug Delivery Using Carrier Red Blood Cells: Focus on RBC Surface Loading and Pharmacokinetics
Glassman PM, Villa CH, Ukidve A, Zhao Z, Smith P, Mitragotri S, Russell AJ, Brenner JS,Muzykantov VR
Supramolecular organization predicts protein nanoparticle delivery to neutrophils for acute lung inflammation diagnosis and treatment
Myerson JW, Patel PN, Habibi N, Walsh LR, Lee YW, Luther DC, Ferguson LT, Zaleski MH, Zamora ME, Marcos-Contreras OA, Glassman PM, Johnston I, Hood ED, Shuvaeva T, Gregory JV, Kiseleva RY, Nong J, Rubey KM, Greineder CF, Mitragotri S, Worthen GS, Rotello VM, Lahann J, Muzykantov VR, Brenner JS
Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier
Marcos-Contreras OA, Greineder CF, Kiseleva RY, Parhiz H, Walsh LR, Zuluaga-Ramirez V, Myerson JW, Hood ED, Villa CH, Tombacz I, Pardi N, Seliga A, Mui BL, Tam YK, Glassman PM, Shuvaev VV, Nong J, Brenner JS, Khoshnejad M, Madden T, Weissmann D, Persidsky Y, Muzykantov VR
Monoclonal antibody 2C5 specifically targets neutrophil extracellular traps
Mendes LP, Rostamizadeh K, Gollomp K, Myerson JW, Marcos-Contreras OA, Zamora M, Luther E, Brenner JS, Filipczak N, Li X, Torchilin VP
Vascular Immunotargeting: Take the Highway to the First Exit
Muzykantov VR, Brenner JS
CRISPR/Cas9-Mediated Genetic Engineering of Hybridomas for Creation of Antibodies that Allow for Site-Specific Conjugation
Khoshnejad M, Brenner JS, Parhiz H, Muzykantov VR
Using selective lung injury to improve murine models of spatially heterogeneous lung diseases
Paris AJ, Guo L, Dai N, Katzen JB, Patel PN, Worthen GS, Brenner JS
Combining vascular targeting and the local first pass provides 100-fold higher uptake of ICAM-1-targeted vs untargeted nanocarriers in the inflamed brain
Marcos-Contreras OA, Brenner JS, Kiseleva RY, Zuluaga-Ramirez V, Greineder CF, Villa CH, Hood ED, Myerson JW, Muro S, Persidsky Y, Muzykantov VR
PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake
Parhiz H, Shuvaev VV, Pardi N, Khoshnejad M, Kiseleva RY, Brenner JS, Uhler T, Tuyishime S, Mui BL, Tam YK, Madden TD, Hope MJ, Weissman D, Muzykantov VR
Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
Brenner JS, Pan D, Myerson J, Marcos-Contreras OA, Villa C, Patel P, Hekierski H, Chatterjee S, Tao JQ, Parhiz H, Bhamidipati K, Uhler T, Hood E, Kiseleva RY, Shuvaev V, Shuvaeva T, Khoshnejad M, Johnston I, Gregory J, Lahann J, Wang T, Cantu E, Armstead W, Mitragotri S, Muzykantov V
Unintended effects of drug carriers: Big issues of small particles
Parhiz H, Khoshnejad M, Myerson JW, Hood E, Patel PN, Brenner JS, Muzykantov VR
Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9
Khoshnejad M, Brenner JS, Motley W, Parhiz H, Greineder CF, Villa CH, Marcos-Contreras OA,Tsourkas A, Muzykantov VR
Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells
Pan DC, Myerson JW, Brenner JS, Patel PN, Anselmo AC, Mitragotri S, Muzykantov V
The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)
Brenner JS, Kiseleva RY, Glassman PM, Parhiz H, Greineder CF, Hood ED, Shuvaev VV,Muzykantov VR
Mechanisms that determine nanocarrier targeting to healthy versus inflamed lung regions
Brenner JS, Bhamidipati K, Glassman P, Ramakrishnan N, Jiang D, Paris AJ, Myerson JW, Pan DC, Shuvaev VV, Villa C, Hood ED, Kiseleva R, Greineder CF, Radhakrishnan R, Muzykantov VR
Nanomedicine for the Treatment of Acute Respiratory Distress Syndrome. The 2016 ATS Bear Cage Award-winning Proposal
Brenner JS
Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury
Paris AJ, Liu Y, Mei J, Dai N, Guo L, Spruce LA, Hudock KM, Brenner JS, Zacharias WJ, Mei HD,Slamowitz AR, Bhamidipati K, Beers MF, Seeholzer SH, Morrisey EE, Worthen GS
Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans
Greineder CF, Hood ED, Yao A, Khoshnejad M, Brenner JS, Johnston IH, Poncz M, Gottstein C,Muzykantov VR
Targeted endothelial nanomedicine for common acute pathological conditions
Shuvaev VV, Brenner JS, Muzykantov VR
Systems approaches to design of targeted therapeutic delivery
Myerson JW, Brenner JS, Greineder CF, Muzykantov VR
Endothelial nanomedicine for the treatment of pulmonary disease
Brenner JS, Greineder C, Shuvaev V, Muzykantov V
TrpC3 regulates hypertrophy-associated gene expression without affecting myocyte beating or cell size
Brenner JS, Dolmetsch RD
Temporal and spatial regulation of calcium-dependent transcription
Brenner JS, Gomez-Ospina N, Dolmetsch RD
